File Explorer in asp.net

http://abeautifulsite.net/blog/2008/03/jquery-file-tree/#usage

Clearing up space on your web-server

When you have tons of virtual directories and multiple deployments that has happened on your web-server. The files are compiled and cached under “C:\WINDOWS\Microsoft.NET\Framework\v2.0.50727\Temporary ASP.NET Files\…”

Removing files from the above folder saves a lot of space

They are safe to be removed, below are a couple of blog posts for reference.

http://stackoverflow.com/questions/586790/eliminating-temporary-asp-net-files

And also they explain how we can change the location of the temp folder to a different drive ( I have not done this because by just deleting some temp files I was able to reclaim around 1GB space)

How to do it http://blog.cwa.me.uk/2007/10/15/relocating-temporary-aspnet-files/

Multiple Site Hosting (Web.config)

Good fix for multiple site hosting
In your root application, try adding

<location path="." inheritInChildApplications="false" >   
</location>

around the system.web element.

The subfolder can be a different site.